Cyclin-dependent kinases (CDKs) are protein kinases involved in critical cellular processes, such as cell cycle or transcription, whose activity requires association with specific cyclin subunits.

The molecular basis of phospho-tyrosyl-regulation of Src-family and Syk-family protein tyrosine kinases in signaling pathways is a current focus of the lab. The conformational activation of Src kinase ...

Engineered kinases remain off in cells until turned ... The researchers also turned to Dokholyan to model protein movement and explain what was happening. Though iFKBP was placed outside FAK's ...

“The genome of most mammals, including humans, contains about 500 protein kinases that regulate nearly all aspects of our biology,” explained Dr. Notredame. “These kinases are major targets ...

With their tools, the researchers can observe how blocking one kinase with an inhibitor sometimes leads to other kinases becoming overactivated, which may explain how cancer cells adapt and ...