KdELECT® Kinase Assay – Broadest Dynamic Range KINOMEscan assays do not require ATP and therefore report true thermodynamic interaction affinities, as opposed to IC50 values, which can depend on the ...

The phosphoinositide 3-kinase (PI3K) pathway is a crucial signal transduction system linking the activation of receptor tyrosine kinases (RTKs), G protein-coupled receptors (GPCRs) and oncogenes ...

Glycogen synthase kinase 3 (GSK3) was initially described ... site of GSK3 by the interaction of axin with GSK3 at a distinct binding site (bottom half of figure). So, drugs that bind to the ...