Mammalian AMP-activated protein kinase (AMPK) was discovered as a ... with the binding of the regulatory nucleotides AMP and ATP. AMP binding to wild-type AMPK appears to prevent the interaction ...

Although inhibitors directed against the ATP-binding site of the kinase, such as imatinib (Glivec/Gleevec; Novartis), lead to clinical remission in the early stage of the disease, most patients ...

Delve into the kinase inhibitors' diverse landscape, from cancer breakthroughs to autoimmune disease innovations.

KdELECT® Kinase Assay – Broadest Dynamic Range KINOMEscan assays do not require ATP and therefore report true thermodynamic interaction affinities, as opposed to IC50 values, which can depend on the ...