ALZFORUM12d
C-Terminal Amidation Sends Proteins to the Shredder
C-terminal amidation is a PTM that involves the addition of an amid group to the C-terminus of a peptide or protein. Currently there is no direct evidence to suggest that C-terminal amidation of ...
Nature7y
A compound chimeric antigen receptor strategy for targeting multiple myeloma
A CML cell line, K562, negative for myeloma markers was induced to express either CS1 (CS1-K562) or BCMA (BCMA-K562). After confirming independent antigen expression in each cell line (Figure 4a ...
Nature15y
Inhibition of imatinib-mediated apoptosis by the caspase-cleaved form of the tyrosine kinase Lyn in chronic myelogenous leukemia cells
We evaluated the effect of LynΔN overexpression on imatinib sensitivity of the chronic myelogenous leukemia (CML) cell line K562. Therefore, we generated stable cells that express plasmids ...