Nanomedicine. 2014;9(1):105-120. SNALP & its Application. SNALP is constructed by three basic lipids: an ionizable cationic lipid (1,2-dilinoleyloxy-3-dimethylaminopropane), a neutral helper lipid ...

LNPs consist of ionizable lipids, which are critical for encapsulating RNA and enabling cellular uptake. Helper lipids contribute to the structural integrity and fusion with cell membranes.

This lipid core provides a hydrophobic environment ideal for encapsulating genetic materials such as messenger RNA (mRNA) or small interfering RNA (siRNA). LNPs typically contain ionizable lipids, ...

To enhance mRNA distribution, Penn engineers have created an ideal “recipe” for ionizable lipids, essential lipid nanoparticles (LNPs) components, the molecules that underlie COVID-19 vaccines ...

Penn Engineers have cooked up a new way to improve mRNA delivery, developing an optimal "recipe" for ionizable lipids -; key ingredients in lipid nanoparticles (LNPs), the molecules behind the ...

However, LNPs consisting of helper lipids, PEGylated lipids and ionizable lipids can be susceptible to N-oxide-based impurities that can cause the loss of function of the genetic payload. To ensure ...

Specifically, I: (i) implemented a lipid-polymer nanoparticle platform for siRNA delivery to bone marrow endothelial cells in vivo to halt myeloma progression, (ii) developed the first-of-its-kind ...