This important study shows that the Nora virus, a natural Drosophila pathogen that also persistently infects many laboratory fly stocks, infects intestinal stem cells (ISCs), leading to a shorter life ...

The work is published in the journal Cell Reports. The intestinal epithelium exhibits the highest cell turnover rate in the adult body, requiring constant and precise regulation of intestinal stem ...

Intestinal stem cells are multipotent adult stem cells, which in mammals reside in the base of the crypts of the adult intestine. Intestinal stem cells continuously self-renew by dividing and ...

In vivo, the intestinal epithelium interacts with the neighboring environment through complex crosstalk, which involves components such as the immune system, tissue microenvironment, and gut microbes.

However, the drug had no effect in CB1IEC−/− mice, further confirming that CB1R in the intestinal epithelium is responsible for alcohol-induced gut barrier disruption. Mechanistic studies ...

Dr. Savidge's lab is focused on emerging research concepts, including the interaction of microbes with epithelium, immune cells and nervous system in the induction of intestinal disease. The team is ...