Figure 1: α v β 3 as a mediator of antiangiogenic regulators. Figure 2: Trans-dominant inhibition of proangiogenic integrins. In presenting these models for negative regulation by α v integrins ...

Integrins are transmembrane glycoproteins that mediate attachment of cells to the extracellular matrix or to other cells via interactions with proteins such as fibronectin and collagen.

The Fagerholm group studies the role of leukocyte integrins in various immune reactions. We are interested in the in vivo roles and regulation of leukocyte beta2-integrins in a healthy and ...

Morphic Therapeutic has lost Johnson & Johnson's Janssen Pharma as a partner, following the termination of an alliance to develop drugs targeting integrins first agreed in 2019. In a filing with ...

She hopes to understand how a protein’s structure influences its function. She uses cryo-EM to study integrins, proteins that help cells communicate and move. Integrins are more flexible than many ...