Guinea-pig insulin was prepared from pancreas by the ... The in vivo assays are cumbersome; they involve the whole animal, made more sensitive to exogenous insulin by endocrine manipulations ...

This is made possible only after the identification of critical pathways involved in immune recognition and rejection of pig islet transplants ... appropriate amount of insulin to control blood ...

She dies after 36 hours. 1993 — A Swedish group headed by Carl Groth is the first to transplant pig islet cells, cells from the pancreas that produce insulin, into patients with diabetes ...