In affected neurons of SCA1 patients and transgenic mice, mutant ataxin-1 accumulates in a single, ubiquitin-positive nuclear inclusion ... 1 aggregation. These data suggest that protein ...

The paper contributes to an ongoing debate about the role of inclusion bodies—intracellular clumps of mutant huntingtin (Htt) protein—in the pathology of diseases like Huntington's and spinocerebellar ...