The gradual accumulation in tissues and organs of permanently damaged cells that don’t die, known as senescent cells, is a hallmark of aging. Both intra- and extracellular stimuli—chemical or ...

After treating a tumor with chemotherapy and radiotherapy, cells known as senescent cells can appear. These are cells that do not divide, are involved in the aging process and are resistant to ...

Studying how and why these spurious transcripts are produced in senescent cells as well as their impact on the cell itself could hold important implications for aging and longevity ...

Traditional methods for detecting senescent cells, such as β-galactosidase staining and immunohistochemistry, have limitations in terms of specificity and sensitivity. The introduction of ...

The little black mouse’s feet dangled above the table as the animal clutched a horizontal wire with its two front paws. After just a few seconds, it lost its grip and fell onto a pile of bedding below ...

Senescent cells can be caused by various mechanisms "such as exposure to chemotherapy and radiotherapy to treat a tumor, as well as the accumulation of cell damage due to aging," says UB professor ...

In the course of their study, the researchers found that diseases associated with aging and obesity are triggered and progress when senescent cells accumulate in internal organs, blood vessels and ...

SASP facilitates immune system activity by recruiting immune cells to remove these senescent cells, thus preserving tissue integrity. Cancer cells frequently encounter stressors that can induce ...