Effective immune responses against infectious agents ... known as a cytolytic immunological synapse, into which they secrete a mixture of toxic perforin and granzymes. Our research efforts in this ...

Led by first author Dr. Ahmed Gad, postdoctoral associate in Ahmed’s lab, the research team examined molecular dynamics at the immune synapse. The team biopsied the CAR T cell immunological ...

We show here active clustering of TCR–MHC molecules at the immune synapse after interaction between aAPC and T cells. This multivalent system allows identification and stimulation of antigen ...

When naive T cells encounter antigen-presenting cells (APCs), membrane and cytoplasmic molecules rearrange at the T cell–APC contact area to form the immune synapse. Finetti et al. now reveal an ...

6 After binding, it induces a non-classical immune synapse (IS), which is essential for effector function. These cells activate anti-tumoral effects via three pathways: cytolytic perforin and ...

The interaction between CD2 and CD58 is critical for forming the immunological synapse, which is pivotal in immune cell activation and adhesion, as well as signaling in both immune and target cells.