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Microvascular over-dilation may lead to muscle hypoxiaThe disease can remain asymptomatic for a long time, but at worst, it can ultimately lead to necrosis and amputation. "Muscle microvasculature responds to hypoxia by dilating in an attempt to ...
How can low oxygen levels lead to developmental abnormality and disease? It seems that proteins called hypoxia-inducible factors (HIFs) can affect gene expression in low-oxygen conditions.
In the 1980s, when Stella Kourembanas, MD, began her career in neonatology, she cared for newborns with pulmonary ...
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Ozone exposure linked to hypoxia and arterial stiffnessRecent studies have linked O 3 exposure with an increased risk of cardiovascular diseases (CVDs), including ischemic heart disease, stroke, heart failure, and atherosclerosis. Hypoxia, or the ...
Elucidation of the roles of additional factors, especially local hypoxia-inducible factors such as HIF1 and pVHL, might give new insights into renal erythropoietin regulation and ultimately lead ...
has conditionally approved WELIREG ® (belzutifan), Merck’s oral hypoxia-inducible factor-2 alpha (HIF-2α) inhibitor, as monotherapy for: The treatment of adult patients with von Hippel-Lindau (VHL) ...
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