High-fat diet (HFD)-induced obesity is characterized by induction of inflammation in the hypothalamus ... intraperitoneal (i.p.) glucose tolerance test after 7 weeks of treatment.

Sucralose also changes how the hypothalamus communicates with other ... Page and her colleagues designed a randomized experiment to test how sucralose changes brain activity, hormone levels ...

Compared to sugar, consuming sucralose—a widely used sugar substitute—increases activity in the hypothalamus, a brain region that regulates appetite and body weight, according to new USC research.