The first CF rat model, CFTR tm1sage (termed CFTR-/- or KO), was designed in collaboration with SAGE (now Horizon Discovery) and subsequently characterized at UAB and distributed to the CF community.

Mice with implanted 20-millimetre-long artificial human livers break down toxins in a way that is closer to how humans do it than traditional lab mice, according to a study published this week (July ...

The discovery of anti-inflammatory and anti-allergy drugs relies heavily on the precise modeling of complex immune mechanisms. However, many traditional cell culture and animal models remain ...

Infectious diseases such as HIV and malaria represent a significant health challenge worldwide. Hence, accurate and expedited research is required to meet the global demand for novel therapeutics and ...

Humanized mouse models, where human tumor tissue is engrafted into immunodeficient mouse models, are now being used in oncology and infectious disease studies to provide valuable translational insight ...