Statins lower plasma cholesterol by upregulating LDL receptor gene expression and are consequently relatively ineffective in homozygous familial hypercholesterolemia (HoFH). The standard treatment ...

Consequently, a test cross can help determine whether a dominant phenotype is homozygous or heterozygous for a specific allele. Diploid organisms, like humans, have two alleles at each genetic ...

Some experts believe that having two mutations (homozygous) may lead to more serious problems. There are two variants, or forms, of mutations that can occur on the MTHFR gene. The specific ...

In its simplest form, a test cross is an experimental cross of an individual organism of dominant phenotype but unknown genotype and an organism with a homozygous recessive genotype (and phenotype).

The study, published in Nature Medicine, also concludes that those individuals homozygous for APOE4 also develop the disease earlier than those with other variants of the APOE gene. These findings ...

Blood tests from children hospitalized with malaria found that nearly all were homozygous for the wild type of sickle cell allele. The few sickle cell carriers among them had the mildest cases of ...

Individuals A and B both have brown eyes, even though A is heterozygous and B is homozygous (dominant). Only people with a homozygous recessive genotype can have blue eyes as shown by individual C.

The medication is currently indicated to treat both children and adults with HeFH and adults with homozygous familial hypercholesterolemia (HoFH).

1 Homozygous for allele r rr Wrinkled 2 Homozygous for allele R RR Round Plants 2 and 3 both have the same phenotype even though they have different genotypes. This is because the effect of allele ...