Homologous recombination plays essential roles in the repair of DNA double strand breaks (DSBs) and collapsed replication forks. The fundamental reaction in homologous recombination is the exchange of ...

Elliott B, Richardson C, Winderbaum J, Nickoloff JA, Jasin M. 1998 Gene conversion tracts from double-strand break repair in mammalian cells in mammalian cells. Mol Cell Biol. 1998;18:93-101. Johnson ...

In four of six cases, the recombination resulting in the duplication occurred between homologous chromosomes (interchromosomal). In one duplication patient (1353), the duplication was derived from ...

Copy number variants (CNVs) arise by homologous recombination (HR) between repeated sequences (recurrent CNVs) or by non-homologous recombination mechanisms that occur throughout the genome (non ...

The mechanism of homologous recombination: Our long-term research objective is to study the mechanisms of homologous recombination in eukaryotic systems. Genetic recombination is the molecular process ...

Hyperthermia is occasionally used to augment the efficacy of certain cancer therapies, but how heat helps has been a mystery. Now, researchers have uncovered the details of one likely mechanism -- ...