Targeted de novo methylation during development involves SET domain-containing proteins that are capable of specifically methylating histones as well as recruiting DNA methyltransferases.

How is all of that DNA packaged so tightly into chromosomes and squeezed into a tiny nucleus? Histones are a family of small, positively charged proteins termed H1, H2A, H2B, H3, and H4 (Van Holde ...

Science never ceases to amaze us, and one of the most mind-blowing facts about the human body is the sheer length of our DNA. If you unraveled all the DNA in your body and laid it out in a straight ...

The team thought it might be a good candidate for finding histones because the bacterium changes size throughout its lifecycle and thus would need to carefully time DNA compression and unwinding. As a ...

Histones proteins were selected early in evolution to transform DNA into chromatin filaments formed by many nucleosomes. The ...

We've now zoomed in enough to see portions of the DNA strand. The DNA is wrapped around histones -- protein structures that are sometimes depicted as discs. Histones carry a slight positive charge ...

The study, published in the prestigious journal EMBO Journal, reveals why some tumors escape the immune system, and offers a ...

The mechanism of a peculiar type of heterochromatin, used by embryonic stem cells to silence 'parasitic' DNA-elements within the context of their highly dynamic pluripotent chromatin. Disclaimer ...

A research led by Sergio P. Acebrón, Researcher Ikerbasque at the UPV/EHU, develops a key tool to visualize the immune response to abnormal DNA, opening new avenues for the treatment of diseases.