Cellular aging involves growth arrest and epigenetic alterations, offering insights into therapeutic approaches for enhancing ...

The basic building blocks of chromatin are nucleosomes, each of which is composed of 146 bp of DNA wrapped around a histone octamer that consists of two copies each of H2A, H2B, H3 and H4.

Epitalon is a synthetic tetrapeptide that has attracted significant interest in longevity and cellular aging research. This peptide, composed of alanine, glutamic acid, aspartic acid, and glycine, has ...

Papers with an asterisk(*) are based on research conducted outside of RIKEN. 1.*Ikeda, T., Uno, M., Honjoh, S. & Nishida, E.: "The MYST family histone acetyltransferase complex regulates stress ...

However, aging and how it contributes to the development of age-associated diseases remain poorly understood. Epigenetic changes, including histone modifications and proteome, are critical regulatory ...

Senescent cells had more acetylated “on” histones and fewer methylated “off” ones, suggesting histone modifications seemingly correlated with cell age expose cryptic sites that are normally hidden in ...

There are several different types of heritable epigenetic marks or modifications, the most established and well-researched of which are histone modifications and DNA methylation. “What's exciting ...

Quantitative analysis of histone post-translational modification and proteoforms in support of understanding ... Grant proposal to elucidate changes in the proteome and mechanism by which protein ...

By Mohana Ravindranath For many people, aging feels like it happens in stops and starts. After a period of smooth sailing, one day, seemingly out of the blue, you have achy knees. “You wake up ...

Researchers identified a gene that seems to help slow brain aging in women, and studied links between hormone therapy, menopause and Alzheimer’s. By Gina Kolata Women’s brains are superior to ...