Histone post-translational modifications (PTMs ... PTMs simultaneously occurring on the same molecule (the histone code). Future proteomics research is heading towards interrogation of histones ...

These observations strongly suggested that two major classes of histone modification might act in opposition to help specify a gene regulatory code for the β-globin gene. That is, transcriptional ...

and phosphorylation (P)), and each mark constitutes a signal that is read alone or in combination with other modifications on the same or neighbouring histones as a 'histone code'. Families of ...

This work is notable for adding support to the controversial histone code hypothesis. The structural work reveals an alpha helix between the PHD finger and a bromodomain. Bromodomain motifs are well ...

1 And in light of this new "histone code" hypothesis, researchers are quick to tout further possibilities in human development, fertility, and other types of cancer. Shelley L. Berger, associate ...

Researchers discovered that a chemical alteration on a single protein, histone ... DNA code. Scientists have long studied the processes that underlie gene expression and the chemical modifications ...

As well as being essential in the precise packaging of DNA into the space of the nucleus, histone proteins are also the site ...

The following is a summary of “Histone Modifications and DNA Methylation in Psoriasis: A Cellular Perspective,” published in the January 2025 issue of Allergy and Immunology by Pan et al. Epigenetic ...

Epigenetic modifications such as DNA methylation and histone acetylation contribute to the profibrotic phenotype of SSc fibroblasts. It has been shown that DNA methylation and histone ...