Recent research has expanded our understanding of lysine methylation beyond its traditional focus on histone proteins, revealing its importance in various non-histone substrates and cellular ...

The samples included seven histone modifications: histone H3 lysine 4 trimethylation (H3K4me3 ... Histone-based predictors were compared to DNA methylation-based predictors, with the study ...

Thus, the decline of estrogen levels or imbalance of these metabolites affects gene expression and underlying brain functions. In the present review, we discussed the importance of DNA methylation and ...

It is important to note that although we have some idea about the propagation of DNA methylation and models ... Figure 4: Propagation of histone 3 lysine 27 trimethylation by polycomb repressive ...

A consortium of specific histone H3 modifications, comprising serine 10 phosphorylation, lysine 9 and 14 acetylation, and lysine 79 methylation, has been identified in muscle biopsy samples from human ...

Objectives In osteoarthritis, methylation of lysine 79 on histone H3 (H3K79me), a protective epigenetic mechanism, is reduced. Histone methylation levels are dynamically regulated by histone ...

Researchers have previously found that the methylation of one particular location, lysine-4, on histone H3, is closely correlated with turning genes "on." Knowing that this relationship exists ...

Understanding how viruses subvert host cell DNA damage response pathways, especially the impact on lysine methyltransferases. Higgs MR†, Sato K, Reynolds JR, Begum S, Bayley R, Goula A, Vernet A, ...

Biochemistry and Molecular Biology, Indiana University School of Medicine (IUSM), 635 Barnhill Drive, Medical Science Building, Indianapolis, Indiana 46202-5122, United States ...

The Taverna Laboratory studies histone marks, such as lysine methylation and acetylation, and how they contribute to an epigenetic/histone code that dictates chromatin-templated functions like ...

Discover how histone modifications unlock secrets of human aging, rivaling the precision of DNA methylation in decoding biological age. In a recent study published in the journal Science Advances ...