Through a unique fabrication technique, "islands" of human hepatocytes are cultured alongside stromal and Kupffer cells in a precise ratio. This setup replicates the liver's physiological ...

and resident Kupffer cells (blue) and from injured hepatocytes (green). Oxidative stress, cytokine release, endotoxin, and ethanol and its metabolites can stimulate paracrine chemokine secretion ...

In the liver, senescence impacts key cell types including hepatocytes, liver sinusoidal endothelial cells, and Kupffer cells, and contributes to chronic liver diseases such as fibrosis ...

3D validated cells Duo-culture Primary human hepatocytes + Kupffer Cells HBV, DILI, Immune-mediated toxicity PhysioMimix OOC, Liver plates, 3D validated cells Tri-culture Primary human hepatocytes ...

On the contrary, there is minimal expression of class I HLA antigens on hepatocytes, which favors decreased antigenicity. It is also thought that donor Kupffer cells may be replaced with host ...