TAGCyx can also attach a proprietary ‘mini-hairpin’ structure (patent granted in Japan and pending elsewhere) to the end of the aptamer, in order to improve tolerability to enzymatic ...

The key to HCR in its simplest form is the storage of potential energy in two hairpin species ... The authors have used this aptamer trigger concept to specifically discriminate ATP from GTP.

Their discovery of a novel mini hairpin structure in a nascent peptide that induces translation arrest sheds light on peptide-mediated regulatory mechanisms.

Unlike antibodies, aptamers' unique structures include hairpin regions (red), which provide stability ... For example, the FDA-approved aptamer drug Pegaptanib (Macugen) targets vascular endothelial ...