including HIV-2 infections. ATP-mediated chain-terminator excision. Thymidine analog-associated mutation-containing reverse transcriptase has enhanced activity for dinucleoside polyphosphate ...

HIV-SEQ identifies mutations and helps in their interpretation ... Table 1 Amino-acid motifs used to align HIV-1 protease and reverse transcriptase sequences Full size table The program then ...

NRTI-resistance mutations & their mechanism of drug ... Stereogram for the 3D structure of HIV-1 reverse transcriptase in complex with a DNA template-primer and dTTP. The p66 subunit of HIV ...

RNA polymerases are sloppy. A retrovirus with an RNA genome, which is copied into DNA by a reverse transcriptase, is prone to mutations because the enzyme lacks the 3’ to 5’ proofreading capability of ...

Viral reverse transcriptase (RT) plays a critical role in replication (e.g., retroviruses, that reverse transcribe RNA templates into complementary DNA) and genome mutations (e.g., diversity ...

More than 46,000 of them had been prescribed a form of HIV-suppressing medications known as reverse transcriptase (RT ... a gene found in neurons undergoes mutations that can produce thousands ...

Efavirenz is a non-nucleoside reverse transcriptase inhibitor (NNRTI), emtricitabine is a nucleoside reverse ... A drug-resistant HIV strain is one which is less susceptible to the effects of one or ...

The four main classes, which most people are treated with, target one of three viral proteins which control HIV’s lifecycle: reverse transcriptase, integrase and protease. Historically, most people ...