为解决静止免疫细胞基因编辑效率低及研究 HIV 感染机制难题，研究人员用 CRISPR-Cas9 编辑体外扁桃体培养的 CD4 + T 细胞，发现能高效敲除基因且不影响细胞功能，对研究 HIV 发病机制和免疫细胞相互作用意义重大。 精准剖析 CD4 + T 细胞与 HIV 病理机制的新突破 在 ...

研究人员解析 HIV-1 包膜糖蛋白三聚体结构，揭示 MPER 作用及 Env 构象调控机制，助力抗 HIV 研究。 研究背景：HIV 研究中的关键谜题 人类免疫缺陷病毒（HIV-1）如同一个隐藏在黑暗中的杀手，悄无声息地破坏着人体的免疫系统，引发获得性免疫缺陷综合征（AIDS）。

The chemokine receptors CCR5 and CXCR4 are the two major coreceptors for HIV entry. Numerous efforts have been made to develop a new class of anti-HIV agents that target these coreceptors as an ...

As sequencing technology and prediction algorithms improve, HIV genotyping and coreceptor usage prediction are likely to play an increasingly important role in guiding patient prognosis and ...

This image shows CCR5 side-by-side with alternate HIV co-receptor CXCR4. While the two share similar overall architecture, their binding pockets show important differences in shape and charge ...

STAGED INVASION: Understanding the role of coreceptors CCR5 and CXCR4 provides a clearer picture of AIDS disease progression, says NIAID's Edward Berger. TAKING AIM: Chemokine receptors provided a ...

HIV-1 entry into cells is an attractive target for new antiviral agents. But will inhibitors aimed at the CCR5 co-receptor force HIV-1 to evolve more virulent forms? Other targets for entry ...

Study findings provide a new gene pathway for potential treatment of the virus affecting millions. Mount Sinai researchers have developed a method to uncover the hidden immune cells that harbor ...