The chemokine receptors CCR5 and CXCR4 are the two major coreceptors for HIV entry. Numerous efforts have been made to develop a new class of anti-HIV agents that target these coreceptors as an ...

T140 Kyoto University Preclinical HIV, cancer metastasis, leukemia, rheumatoid arthritis A downsized analog of T22 peptide that specifically inhibits CXCR4 KRH-3955 Kureha Preclinical HIV ...

Computational analysis of the variations in the HIV-1 genome sequence that correlate with preferential binding to the CCR5 (C-C-motif receptor 5) or CXCR4 (C-X-C motif receptor 4) coreceptors in ...

But will inhibitors aimed at the CCR5 co-receptor force HIV-1 to evolve more virulent forms? Other targets for entry inhibitors include two co-receptors on the cell surface—CCR5 and CXCR4 ...

STAGED INVASION: Understanding the role of coreceptors CCR5 and CXCR4 provides a clearer picture of AIDS disease progression, says NIAID's Edward Berger. TAKING AIM: Chemokine receptors provided a ...