The application of HDAC inhibitors for the treatment of various CNS disorders has emerged in recent years. Chromatin remodelling and transcriptional modulation may underlie the efficacy of HDAC ...

22 Future research should explore the relationship between kynurenine metabolism and HDAC inhibition, considering novel inhibitors that could enhance treatment efficacy. Investigating NAD+ metabolism ...

HDAC inhibitors are already on the market for cancer and some other indications – including Duchenne muscular dystrophy. However, the development of selective HDAC6 inhibitors for cancer has ...