After receptor binding, the lipid envelope of HCV dissociates and host ribosomes translate the viral genomic RNA into viral proteins. The flanking untranslated regions of the HCV genome (5′ UTR ...

Sex hormone impact on the HCV life cycle. 1. HCV enters the host cells through cell surface receptors CD81, SR-B and LDLR. Tight junction proteins OCLN and CLDN are co-receptor molecules important ...

Ideally, entry inhibitors block viral binding to the host (co)receptors without affecting their physiological function. Presumably, future anti-HCV therapies will be combinations of drugs ...