Talampanel blocks the AMPA receptor, a glutamate receptor that is present on both neurons and glial cells. Gliomas tend to produce excess glutamate, which is toxic to nearby glia and neurons ...

The team found that most of the glioma-innervating neurons extending from the far reaches of the brain are the type that makes glutamate, a major brain chemical that excites neurons. This finding ...

We have investigated the role of mitochondrial calcium buffering in excitotoxic cell death. Glutamate acts at NMDA receptors in cultured rat forebrain neurons to increase the intracellular free ...