It can be inherited (hereditary gingival fibromatosis [HGF]); associated with other diseases characterizing a syndrome; or induced as a side effect of systemic drugs, such as phenytoin ...

Hereditary Gingival Fibromatosis (HGF) is a rare genetic condition characterized by the progressive overgrowth of gum tissue, which can lead to aesthetic, phonetic, and masticatory issues.

As such, they are reported to be useful for the treatment of cancer, gingival fibromatosis, cardiofaciocutaneous and Noonan syndromes.