We functionally characterized a GATA2 mutant allelic series representing major disease phenotypes caused by germline and somatic (s) mutations in zinc finger 2 (ZF2). All GATA2 mutants ...

A germ-line mutation looks like a red ball in a sea of white balls—difficult, but not impossible, to spot; a somatic mutation is gray, and more easily blends in. “In genetics, it can be hard ...

Instead, each individual cancer draws on a collection of acquired mutations that endow the cells with a selective advantage and superior ... Patients with this cancer type had an earlier cancer onset ...