Nature5 年
Familial gastrointestinal stromal tumours with germline mutation of the KIT gene
You have full access to this article via your institution. Figure 1: A family with multiple GISTs and mutation of the KIT gene.
STAT7 天
At meeting on guardrails for gene editing of human embryos, some call for a dead end
At meeting on human embryo editing, CRISPR pioneer says science is a long way from knowing if germline DNA can be safely ...
BRCA-mutation carriers with history of early-onset breast cancer may benefit from risk ...
Patients with germline BRCA mutations who were diagnosed with breast cancer at or before age 40 and who underwent a bilateral risk-reducing mastectomy (RRM) and/or a risk-reducing ...
Frontiers23 天
New Insights into Cancer Predisposition Syndromes in Pediatric Hematology-Oncology
Hereditary predisposition is a relevant cause of cancer in children and adolescents. At least 10% of all pediatric tumors are due to germline mutations in cancer predisposition genes. Although Cancer ...
来自MSN1 个月
BRCA1 gene mutations may not be key to prostate cancer initiation, as previously thought
Germline BRCA 1 and BRCA 2 test results were available for all 450 men. These revealed 27 germline BRCA2 variants (6%), but only two germline BRCA1 variants (0.5%), and one of these probably wasn ...
pharmaphorum3 天
GSK hits another oncology hurdle as Zejula use is limited again
means it can only be used as second-line maintenance therapy after platinum-based chemotherapy in patients with these cancers whose tumours carry a germline BRCA mutation – around 15% of the ...