a technique known as gene knockdown. 8 By delivering dsRNA that are complementary to a target gene’s mRNA, researchers redirect the RNAi pathway from its canonical functions to cleave the target and ...

The method, reported today (October 5) in Nature Materials, provides a new way to study the functions of adipocytes—a notoriously intractable cell type—and suggests an avenue for gene therapy to ...

Transform the verified clones into the cell lines of interest to test their ability to knock down gene expression. The vector(s) may be transiently transfected into any commonly used cell line ...

The Phase Ib trial is set to test a gene therapy designed to target a rare disorder that causes muscle and respiratory failure.

Using lentivirus to express shRNA, for RNAi-mediated gene knockdown, or ORF, for gene overexpression, we can rapidly assess gene function and complex genetic interactions in skin morphogenesis and ...