During the elongation cycle of protein biosynthesis on the ribosome ... Domain I comprises two subdomains, the GTP-binding G domain and an insertion, the G' domain. Recently, using cryo-electron ...

This important study demonstrates the potential of synthetic gene circuits to detect and target aberrant RAS activity in cancer cell lines. The circuit design is novel and the evidence supporting the ...

in the protein regulation process. Xiong has identified a key regulator for GTPase function called CalDAG-GEFI (CDGI) to control the switch of binding GTP or GDP of LRRK2 GTPase. Most other ...