最近有研究开发了谷胱甘肽响应型药物递送系统，这类递送系统利用肿瘤微环境中谷胱甘肽水平升高来实现药物的靶向释放。然而，这些方法主要依赖于化疗药物，这限制了它们对耐药肿瘤的疗效。此外，这些方法还忽视了协同策略，例如葡萄糖饥饿或基于活性氧的疗法，这些策略能够进一步增强抗肿瘤效果，同时降低全身毒性作用。

Reduced glutathione or simply glutathione (γ-glutamylcysteinylglycine; GSH) is found in the cytosol of most cells of the body. GSH in the epithelial lining fluid (ELF) of the lower respiratory ...

However, the liver's robust antioxidant defenses, including glutathione (GSH) and vitamin E, question the widespread applicability of ferroptosis as a primary mode of cell death in DILI.

It responds to elevated glutathione (GSH) levels, a molecule abundant in tumour cells. Upon encountering high GSH levels, the hydrogel triggers a controlled drug release directly into the tumour ...

However, the liver's robust antioxidant defenses, including glutathione (GSH) and vitamin E, question the widespread applicability of ferroptosis as a primary mode of cell death in DILI.