Transcription factors (TFs) are key cellular components that control gene expression. Their activity determines how cells function and respond to cellular environments. Despite intense scientific ...

These TF-specific structural states may direct gene-specific regulatory events; in other words, Mediator—a general transcription factor—may acquire gene-specific functions that are triggered by TF ...

Transcription factors are proteins involved in the process of converting, or transcribing, DNA into RNA. Transcription factors include a wide number of proteins, excluding RNA polymerase ...

Protein synthesis is vital for life, translating genetic information from DNA to functional proteins through transcription ...

The complex structure and function of Mediator. J Biol Chem ... Architecture of the human and yeast general transcription and DNA repair factor TFIIH. Mol Cell 2015, 59: 794 – 806. Allen, BL; Taatjes, ...

A multi-institutional team of investigators have developed a catalog of transcription factor binding sites that regulate gene ...

Specifically, we investigate how 3′UTRs regulate protein functions in a manner that is independent of protein abundance. We found that inclusion or exclusion of the 3′UTR of an mRNA that encodes a ...

Citrus fruit rind color has long been used as an indicator of ripeness, but for some fruits such as mandarin fruit in the ...

Andrew Teschendorff, Professor at the Chinese Academy of Sciences, is developing computational systems-biological tools to ...

The transcription factor CDX2—which plays an important role in the development and function of the digestive system—is a key mediator of these differences in proximal (right) colon stem cells ...