A novel protein cage system can control and visualize orientational changes in aromatic side chains upon ligand binding. By inducing coordinated molecular changes, this approach enables precise ...

The key to this is the modification of the original ligand with a reactive "handle ... the approach is highlighted by the first covalent "fluorescent light-up RNA aptamer" (coFLAP).

Single-molecule imaging, a technique that uses fluorescent markers to track proteins with precision, plays a crucial role in cell biology, biochemistry, molecular biology, and drug discovery.