This direct route avoids gastrointestinal destruction and hepatic first pass metabolism of these drugs, effectively increasing their bioavailability and cost-effectiveness, while decreasing time ...

A possible explanation is differences in first-pass metabolism among individual ... the rectal suppositories resulted in a mean 16% lower bioavailability compared with the 50-mg oral syrup.

BOSTON - Seaport Therapeutics, a clinical-stage biopharmaceutical company, has published new research demonstrating significant advancements in drug delivery through the lymphatic system using its ...

which is uniquely designed to enable oral bioavailability, bypass first-pass metabolism and reduce liver enzyme elevations or hepatotoxicity and other side effects. Seaport is led by an ...