Historically, LPO and iron-catalyzed free radical generation were central to understanding DILI, but the focus shifted toward apoptosis in the late 20th century. The discovery of ferroptosis—a ...

Glaucoma is a complex and multifactorial neurodegenerative disorder primarily characterized by the progressive loss of retinal ganglion cells (RGCs) and their axons, leading to irreversible visual ...

Using this approach, we found compounds that induce apoptosis, necrosis, and a novel form of regulated cell death. These novel compounds induce a non-apoptotic, iron-dependent oxidative form of cell ...

Historically, LPO and iron-catalyzed free radical generation were central to understanding DILI, but the focus shifted toward apoptosis in the late 20th century. The discovery of ferroptosis-; a ...

Although it was once thought that most programmed cell deaths occurred by the caspase-dependent program apoptosis, now numerous non-apoptotic programs have been ... with large nutrient stores that ...

Cell biologist Michael Overholtzer explains apoptosis, a form of programmed cell death that can lead to cancer when ... Riegman M, Sagie L, Galed C, Levin T, Steinberg N, Dixon SJ, Wiesner U, ...