Megakaryocytes form a three-dimensional (3D) cage composed of laminin and collagen IV connected to the basement membrane surrounding them. This microarchitecture stabilizes megakaryocytes within their ...

Physiological extracellular matrix (ECM) calcification or mineralization is restricted to bones, teeth and the hypertrophic zone of growth plate cartilage. In contrast, pathological ECM ...

Discover the power of hydrogel: researchers at Penn State mimic tissue behaviors using special hydrogels for potential ...

The extracellular matrix protein fibronectin forms fibrils ... During the assembly of the fibronectin fibrils found in the ECM, the stretching of fibronectin might expose these potential ...

然而，目前用于荧光标记细胞外生物分子的方法在活体组织应用中存在诸多挑战。基于蛋白质的亲和试剂（如抗体和凝集素），由于空间扩散性差，难以在组织中有效分布；病毒递送标记的高分子量 ECM 成分，受到病毒包装限制；内源性遗传标签则需要大量优化，以避免干扰 ECM 的正常组装，而这对于生物体的发育至关重要。此外，现有方法难以实现多重标记，无法全面展示 ECM ...

Explore the role of the extracellular matrix (ECM) in prostate cancer progression and discover natural therapies, including milk thistle, turmeric, and green tea, that target the tumor ...

A biomaterial that can mimic certain behaviors within biological tissues could advance regenerative medicine, disease ...

The numerous cells that make up mammalian tissues are surrounded by an intricate network of proteins known as the extracellular matrix (ECM). Together, these proteins provide cells with a structural ...

Liu from the department of pharmacy, University of Electronic Science and Technology of China, discovered that the extracellular cell matrix (ECM) could induce the drug resistance of breast cancer ...

My group is interested in understanding the role of extracellular matrix internalisation in invasive cell migration and cell growth. The extracellular matrix (ECM) is a complex network of secreted ...

Hepatic fibrosis is a reversible wound healing response characterized by accumulation of extracellular matrix (ECM), or "scar," that follows chronic but not self-limited liver disease. The ECM ...

The Under-oil Open Microfluidic System enhances tumor cell-ECM interaction studies, improving anti-metastatic drug testing for triple-negative breast cancer.