然而，目前用于荧光标记细胞外生物分子的方法在活体组织应用中存在诸多挑战。基于蛋白质的亲和试剂（如抗体和凝集素），由于空间扩散性差，难以在组织中有效分布；病毒递送标记的高分子量 ECM 成分，受到病毒包装限制；内源性遗传标签则需要大量优化，以避免干扰 ECM 的正常组装，而这对于生物体的发育至关重要。此外，现有方法难以实现多重标记，无法全面展示 ECM ...

The extracellular matrix protein fibronectin forms fibrils ... During the assembly of the fibronectin fibrils found in the ECM, the stretching of fibronectin might expose these potential ...

Physiological extracellular matrix (ECM) calcification or mineralization is restricted to bones, teeth and the hypertrophic zone of growth plate cartilage. In contrast, pathological ECM ...

About PYX-201 PYX-201, an antibody-drug conjugate (ADC) with a microtubule inhibitor (optimized auristatin) payload that uniquely targets Extradomain-B Fibronectin (EDB+FN), a non-cellular structural ...

A biomaterial that can mimic certain behaviors within biological tissues could advance regenerative medicine, disease ...

The Under-oil Open Microfluidic System enhances tumor cell-ECM interaction studies, improving anti-metastatic drug testing for triple-negative breast cancer.

The numerous cells that make up mammalian tissues are surrounded by an intricate network of proteins known as the extracellular matrix (ECM). Together, these proteins provide cells with a structural ...

Liu from the department of pharmacy, University of Electronic Science and Technology of China, discovered that the extracellular cell matrix (ECM) could induce the drug resistance of breast cancer ...

Keith Burridge (Department of Cell Biology and Anatomy, University of North Carolina, Chapel Hill): "The extracellular matrix (ECM) influences the growth, differentiation, motility, and morphologyof ...

Explore the role of the extracellular matrix (ECM) in prostate cancer progression and discover natural therapies, including ...

Hepatic fibrosis is a reversible wound healing response characterized by accumulation of extracellular matrix (ECM), or "scar," that follows chronic but not self-limited liver disease. The ECM ...

Pyxis Oncology (PYXS) announced significant progress in its clinical program for PYX-201, a first-in-concept antibody-drug conjugate, ADC, that ...