Antigen-presenting cells work to present peptides derived from exogenous and endogenous antigens to circulating T cells, sparking off an immune response. Dendritic cells are unique amongst antigen ...

Although the above examples all rely on macroautophagy, chaperone-mediated autophagy also contributes to MHC class II-restricted presentation of endogenous antigens 52. In this case, lysosome ...

Certain peptides are preferentially loaded onto MHC I, further processed for immune surveillance (antigen processing) and presented on the cell surface. Peptides that come from normal endogenous ...