known as a T cell, becomes exhausted, according to a new study that points the way for important new lines of investigation. The study's authors knew the immune system was dysregulated in patients ...

Prolonged illnesses like cancer and chronic infections often leave the immune system in a state of exhaustion, where its ...

By screening FDA-approved drugs, they discovered that miltefosine—a small molecule previously used to treat leishmaniasis—could restore the functionality of exhausted CAR-T cells. Remarkably ...

Researchers have identified a rare type of immune cells that hold the key to maintaining long-term immune responses.

The firm will study its autologous cell therapy alone and in combination with Eisai's Lenvima in patients with hepatitis B-driven hepatocellular carcinoma.

becoming significantly upregulated upon T cell activation and further enriched in exhausted T cells within the tumor microenvironment (TME). This makes P4HA1 a highly selective target for ...