Revealing the fundamental principles of how neural circuits are organized and operate is a key challenge in neuroscience. In the past 60 years, intensive effort has been invested in characterizing ...

A fluorescent probe designed to incorporate a fluorophore into the structure of a neurotransmitter finds activity-dependent heterogeneity in dopamine release at individual synapses ...

Neurotransmitters are often described as excitatory or inhibitory because they can activate or inhibit specific actions of their target cell. Each neurotransmitter can have various effects on diff ...

As the brain's most abundant excitatory neurotransmitter, glutamate facilitates our ability to learn, form memories, and regulate our mood. Yet this powerful neurotransmitter can become both ...

Glutamate, the main excitatory neurotransmitter in the central nervous system, is involved in cognitive functions such as learning and memory. Excitatory amino acid transporters (EAATs) present on the ...

However, a series of weak stimuli can combine, increasing the amount of neurotransmitter that is released. This results in enough neurotransmitter being diffused across the synaptic cleft to ...

The fatigue that comes from performing demanding mental tasks may stem from a buildup of the neurotransmitter glutamate, according to research published today (August 11) in Current Biology. Mental ...

There are two types of removal: Re-uptake – the neurotransmitter is reabsorbed back into the presynaptic neuron and restored inside a vesicle ready to be used again. For example, noradrenaline.

This is a thin section of brain showing GABA-releasing SST+ interneurons (green) and other interneurons (red). Increasing GABA signaling specifically in SST+ interneurons has antidepressant ...