随着基因编辑技术的飞速发展，研究人员看到了治疗线粒体疾病的新曙光。近年来，一种新兴的基因编辑工具——转录激活因子样效应子连接的脱氨酶 (Transcription activator-like effector-linked deaminase, ...

Living cells respond to DNA damage by a variety of mechanisms, including a series of biochemical pathways called DNA repair. These include three discrete pathways for the excision of damaged bases ...

it coordinates potentially dangerous steps in the base excision repair pathway. Figure 1: Schematic representation of single-nucleotide BER and alternatives for aborted intermediates. Recent ...

Sunburns and aging skin are obvious effects of exposure to harmful UV rays, tobacco smoke and other carcinogens. But the effects aren't just skin deep. Inside the body, DNA is literally being torn ...

Researchers at Georgia State University used the Summit supercomputer to study an elaborate molecular pathway called ...

Repair reactions involve the excision of chemically altered or mispaired bases from the DNA duplex. Resulting gaps are filled in by DNA polymerases; this reaction leaves a nick at or flanking the site ...

Research shows UV radiation modifies 3D genome structure, affecting DNA damage response and gene activity, offering insights ...

Open’s bonnet, takes a deep breath and says, “It will cost you.” Scientists have harnessed the Summit supercomputer's raw computational muscle to examine how cells repair DNA damage. Using Summit’s ...

Colorectal Surgery with Transanal Excision procedure is an option for patients needing colon or rectal removal. In this procedure, the surgeon removes the colon or rectum and the surrounding tissue ...

Marking a breakthrough in advanced ophthalmic care, Dr Agarwals Eye Hospital successfully performed a complex surgical ...