She and her colleagues had developed a knockout mouse deficient in type 2 deiodinase (D2), an enzyme that was thought ... She expected the knockouts, with their extremely low levels of brain T3, to be ...

The Knockout Mouse Phenotyping Program (KOMP2) sites at Baylor College of Medicine, Jackson Laboratory, and University of California, Davis, are collaborating with the International Mouse Phenotyping ...

In this case, heterozygous knockout mice are repeatedly backcrossed ... phenotypic variability between two strains (for example, if a mouse congenic for the region has a immune or disease ...

As extrapolated from the above example, knockout and ENU mutant alleles with chromosome substitution strains and collaborative crosses, which have been developed only in the mouse, will together ...

For example ... created a game-changing new mouse model. By using CRISPR-Cas9, they deleted the FIRE sequence, which is a super enhancer in the gene encoding CSF1R, a receptor required for microglia ...