The starting dose should be reduced to 25 mg once daily in patients receiving weak CYP3A4 inhibitors (such as erythromycin, saquinavir, verapamil, and fluconazole). Inspra (eplerenone tablets ...

In a multicenter, 8-week trial in 417 essential hypertensive patients eplerenone 50, 100, or 400 mg o.d. or 25, 50 or 200 mg b.i.d. was compared with spironolactone 50 mg b.i.d. or placebo.