The pathologic changes characteristic of ALI/ARDS ... epithelial cell death and activation of proinflammatory pathways, which gives rise to the clinical entity known as ventilator-induced lung ...

Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) clinical criteria include ... Diffuse alveolar damage - Disruption and loss of both epithelial and endothelial cells - Exudation ...

Airway epithelial cells act as a physical barrier against environmental toxins and injury, and modulate inflammation and the immune response. As such, maintenance of their integrity is critical.

MG is a founder member of the UK and Ireland Acute Lung Injury Research Group and Chair of the Intensive Care Society Guideline Development Group for the Management of ARDS. His clinical and research ...