Small-molecule enzyme-inhibitors often display insufficient affinity and selectivity for their targets causing unwanted side effects when used as drugs. Molecularly imprinted polymers prepared ...

Cardiovascular diseases are the world's leading cause of death, and high blood pressure, or hypertension, affects more than 1 ...

Hypotension is not a specific side effect with ACE inhibitors; rather, it is a broadening of the physiologic action of these drugs that occurs most commonly when a patient becomes volume contracted.

Inside cells, two important enzymes act like small central regulatory hubs: dipeptidyl peptidase 8 and 9—DPP8/9 for short.

These inhibitors, which form the basis of many anti-cancer drugs currently in development, disrupt cell division by blocking the USP28 enzyme. The problem is that they often act not only against ...

Using computational tools and virtual screening, researchers at the Center for Redox Processes in Biomedicine (Redoxoma) have identified new inhibitors of the enzyme human 15-lipoxygenase-2 (h15 ...

High blood pressure, or hypertension, affects more than a billion people worldwide and remains the leading cause of death due ...

Scientists have found a surprising new way to make certain cancer drugs work dramatically better – by helping them get inside ...

Most NSAIDs affect levels of both Cox-1 and Cox-2 enzymes. Cox-2 inhibitors only block the Cox-2 enzyme. So these drugs don't affect the prostaglandins that protect the lining of your GI tract.

INSTIs block integrase, an enzyme that HIV uses to put HIV DNA into human DNA inside the CD4 T cells. INSTIs belong to a category of drugs known as integrase inhibitors. INSTIs are well ...

A new discovery could pave the way for more effective cancer treatment by helping certain drugs work better inside the body.