"Enhancer-gene maps" link genomic regulatory regions to genes and are essential for understanding disease. But constructing them poses challenges due to limitations in current experimental methods ...

Enhancer Biology lab studies gene regulation and genome architecture controlled by transcription factors using genome-wide functional genomics methods. Our aim is to understand enhancer malfunction ...

A noncoding DNA sequence in or near a gene required for proper spatiotemporal ... Often used interchangeably with enhancer.

The DNA of plants and animals contains their blueprint. However, genes, the instructions for generating proteins, are found in a very small portion of the genome, roughly 2% in mammals. The ...

Post-mortem examination of a mouse heart shows a clear delineation in blue where TREE gene enhancer sensed and responded to tissue damage of a heart attack. photo - Ken Poss Lab, Duke University ...