In eukaryotic cells, the ER is the site of three major physiologic functions: protein folding, intracellular Ca 2+ storage, and synthesis of unsaturated fatty acids, sterols, and phospholipids (10).

Thomas Ostwald and David MacLennan were characterizing proteins that bind to calcium in the sarcoplasmic reticulum — a specialized type of endoplasmic reticulum found in muscle cells.

The story begins in the endoplasmic reticulum—the cellular ... wrinkled mess of fabric, but when folding fails among the approximately 7,000 proteins with an origami-like complexity that ...

Protein disulfide isomerases (PDIs) are essential enzymes that facilitate the proper folding of proteins and maintain protein quality within the ...

Background and objectives Protein disulfide isomerases (PDIs) are essential enzymes that facilitate the proper folding of ...

Our research focuses on studies on the molecular structure and mechanism of proteins, recently mostly on the endoplasmic reticulum proteins involved in cellular stress signalling, including in ...